Publications

Targeted Lung Denervation Bibliography

Valipour, A., Shah, P. L., Pison, C., (…) Slebos, D.J. on behalf of the AIRFLOW-1 Study Group (2019) Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients. Respiration 2019. doi: 10.1159/000500463 (epub)

Hummel, J. P., Mayse, M. L., Dimmer, S., & Johnson, P. J. (2019) Physiologic and histopathologic effects of targeted lung denervation in an animal model. J Appl Physiol (1985), 126(1), 67-76. doi: 10.1152/japplphysiol.00565.2018

Valipour, A., Asadi, S., Pison, C., Jondot, M., Kessler, R., Benneddif, K., (. . .) Mayse, M. (2018). Long-term safety of bilateral targeted lung denervation in patients with COPD. Int J Chron Obstruct Pulmon Dis, 13, 2163-2172. doi: 10.2147/COPD.S158748

Koegelenberg, C. F., Theron, J., Slebos, D. J., Klooster, K., Mayse, M., & Gosens, R. (2016).
Antimuscarinic Bronchodilator Response Retained after Bronchoscopic Vagal Denervation in Chronic Obstructive Pulmonary Disease Patients. Respiration, 92(1), 58-60. doi: 10.1159/000447641

Kistemaker, L. E., Slebos, D. J., Meurs, H., Kerstjens, H. A., & Gosens, R. (2015). Anti- inflammatory effects of targeted lung denervation in patients with COPD. Eur Respir J, 46(5), 1489-1492. doi: 10.1183/13993003.00413-2015

Slebos, D. J., Klooster, K., Koegelenberg, C. F., Theron, J., Styen, D., Valipour, A., (. . .) Bolliger, C. T. (2015). Targeted lung denervation for moderate to severe COPD: a pilot study. Thorax, 70(5), 411-419. doi: 10.1136/thoraxjnl-2014-206146

Targeted Lung Denervation Mechanism of Action Bibliography

Download PDF

Zaccone, E. J., & Undem, B. J. (2016). Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections. Lung, 194(1), 25-29. doi: 10.1007/s00408-015-9832-5

Zaccone, E. J., Lieu, T., Muroi, Y., Potenzieri, C., Undem, B. E., Gao, P., (. . . )Undem, B. J. (2016). Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways. PLoS One, 11(5), e0155526. doi: 10.1371/journal.pone.0155526

Zanini, A., Cherubino, F., Zampogna, E., Croce, S., Pignatti, P., & Spanevello, A. (2015). Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 10, 1155-1161. doi: 10.2147/COPD.S80992

McAlexander, M. A., Gavett, S. H., Kollarik, M., & Undem, B. J. (2015). Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse. Respir Physiol Neurobiol, 212-214, 20-24. doi: 10.1016/j.resp.2015.03.007

Trankner, D., Hahne, N., Sugino, K., Hoon, M. A., & Zuker, C. (2014). Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci USA, 111(31), 11515-11520. doi: 10.1073/pnas.1411032111

van den Berge, M., Vonk, J. M., Gosman, M., Lapperre, T. S., Snoeck-Stroband, J. B., Sterk, P. J., (…) Postma, D. S. (2012). Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J, 40(5), 1098-1105. doi: 10.1183/09031936.00169711

de Nijs, S. B., Fens, N., Lutter, R., Dijkers, E., Krouwels, F. H., Smids-Dierdorp, B. S., (. . .) Sterk, P. J. (2011). Airway inflammation and mannitol challenge test in COPD. Respir Res, 12, 11. doi: 10.1186/1465-9921-12-11

Zhang, G., Lin, R. L., Wiggers, M., Snow, D. M., & Lee, L. Y. (2008). Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol, 586(23), 5771-5786. doi: 10.1113/ jphysiol.2008.161042

Canning, B. J. (2006). Reflex regulation of airway smooth muscle tone. J Appl Physiol (1985), 101(3), 971-985. doi: 10.1152/japplphysiol.00313.2006

Chuaychoo, B., Hunter, D. D., Myers, A. C., Kollarik, M., & Undem, B. J. (2005). Allergeninduced substance P synthesis in large-diameter sensory neurons innervating the lungs. J Allergy Clin Immunol, 116(2), 325-331. doi: 10.1016/j.jaci.2005.04.005

Wedzicha, J. A. (2004). Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc, 1(2), 115-120. doi: 10.1513/pats.2306030

Sethi, S., Evans, N., Grant, B. J., & Murphy, T. F. (2002). New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med, 347(7), 465-471. doi: 10.1056/NEJMoa012561

Myers, A. C., Kajekar, R., & Undem, B. J. (2002). Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol, 282(4), L775-781. doi: 10.1152/ajplung.00353.2001

Carr, M. J., Hunter, D. D., Jacoby, D. B., & Undem, B. J. (2002). Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med, 165(8), 1071-1075. doi: 10.1164/ajrccm.165.8.2108065

Seemungal, T., Harper-Owen, R., Bhowmik, A., Moric, I., Sanderson, G., Message, S., (. . .) Wedzicha, J. A. (2001). Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 164(9), 1618-1623. doi: 10.1164/ajrccm.164.9.2105011

Hospers, J. J., Postma, D. S., Rijcken, B., Weiss, S. T., & Schouten, J. P. (2000). Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet, 356(9238), 1313-1317. doi: 10.1016/S0140-6736(00)02815-4

Costello, R. W., Evans, C. M., Yost, B. L., Belmonte, K. E., Gleich, G. J., Jacoby, D. B., & Fryer, A. D. (1999). Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. Am J Physiol, 276(5), L709-714. doi: 10.1152/ajplung.1999.276.5.L709

Grunberg, K., Timmers, M. C., Smits, H. H., de Klerk, E. P., Dick, E. C., Spaan, W. J.,( . . .) Sterk, P. J. (1997). Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy, 27(1), 36-45.

Sorkness, R., Clough, J. J., Castleman, W. L., & Lemanske, R. F., Jr. (1994). Virus-induced airway obstruction and parasympathetic hyperresponsiveness in adult rats. Am J Respir Crit Care Med, 150(1), 28-34. doi: 10.1164/ajrccm.150.1.8025764

Laitinen, L. A., Elkin, R. B., Empey, D. W., Jacobs, L., Mills, J., & Nadel, J. A. (1991). Bronchial hyperresponsiveness in normal subjects during attenuated influenza virus infection. Am Rev Respir Dis, 143(2), 358-361. doi: 10.1164/ajrccm/143.2.358

Fryer, A. D., & Jacoby, D. B. (1991). Parainfluenza virus infection damages inhibitory M2 muscarinic receptors on pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol, 102(1), 267-271. doi: 10.1111/j.1476-5381.1991.tb12164.x

Buckner, C. K., Songsiridej, V., Dick, E. C., & Busse, W. W. (1985). In vivo and in vitro studies on the use of the guinea pig as a model for virus-provoked airway hyperreactivity. Am Rev Respir Dis, 132(2), 305-310. doi: 10.1164/arrd.1985.132.2.305

Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., & Nadel, J. A. (1976). Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis, 113(2), 131-139. doi: 10.1164/arrd.1976.113.2.131