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Targeted Lung Denervation Bibliography

Hartman JE, Conway F, Degano B, Augustijn SWS, Herth FJF, Mayr A, Chacaroun S, Tonkin J, Valipour A, Slebos DJ. Rate of lung function decline slows in the 3 years after targeted lung denervation in COPD. Respir Med 2021; 188: 106604.

Hartman JE, Srikanthan K, Caneja C, Ten Hacken NHT, Kerstjens HAM, Shah PL, Slebos DJ. Bronchoscopic Targeted Lung Denervation in Patients with Severe Asthma: Preliminary Findings. Respiration; international review of thoracic diseases 2021: 1-6.

Pison C, Shah PL, Slebos DJ, Ninane V, Janssens W, Perez T, Kessler R, Deslee G, Garner JL, Hartman JE, Degano B, Mayr A, Mayse M, Peterson AD, Valipour A. Safety of denervation following targeted lung denervation therapy for COPD: AIRFLOW-1 3-year outcomes. Respir Res 2021; 22: 62.

Valipour A, Shah PL, Herth FJ, Pison C, Schumann C, Hübner RH, Bonta PI, Kessler R, Gesierich W, Darwiche K, Lamprecht B, Perez T, Skowasch D, Deslee G, Marceau A, Sciurba FC, Gosens R, Hartman JE, Conway F, Duller M, Mayse M, Norman HS, Slebos DJ. Two-Year Outcomes for the Double-Blind, Randomized, Sham-Controlled Study of Targeted Lung Denervation in Patients with Moderate to Severe COPD: AIRFLOW-2. International Journal of Chronic Obstructive Pulmonary Disease 2020; 15: 2807-2816.

Mayse ML, Norman HS, Peterson AD, Rouw KT, Johnson PJ. Targeted lung denervation in sheep: durability of denervation and long-term histologic effects on bronchial wall and peribronchial structures. Respir Res 2020; 21: 117.

Slebos DJ, Degano B, Valipour A, Shah PL, Deslee G, Sciurba FC, Group A-TS. Design for a multicenter, randomized, sham-controlled study to evaluate safety and efficacy after treatment with the Nuvaira(R) lung denervation system in subjects with chronic obstructive pulmonary disease (AIRFLOW-3). BMC Pulm Med 2020; 20: 41.

Valipour A, Mayse ML, Peterson AD, Johnson PJ, Rouw KT, Asadi S, Hummel JP. Respiratory Sinus Arrhythmia Attenuation via Targeted Lung Denervation in Sheep and Humans. Respiration; international review of thoracic diseases 2019: 1-6.

Slebos DJ, Shah PL, Herth FJ, Pison C, Schumann C, Hubner RH, Bonta PI, Kessler R, Gesierich W, Darwiche K, Lamprecht B, Perez T, Skowasch D, Deslee G, Marceau A, Sciurba FC, Gosens R, Hartman JE, Srikanthan K, Duller M, Valipour A, Group A-TS. Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe COPD (AIRFLOW): A Multicenter Randomized Controlled Trial. American journal of respiratory and critical care medicine

Valipour, A., Shah, P. L., Pison, C., (…) Slebos, D.J. on behalf of the AIRFLOW-1 Study Group (2019) Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients. Respiration 2019. doi: 10.1159/000500463 (epub)

Hummel, J. P., Mayse, M. L., Dimmer, S., & Johnson, P. J. (2019) Physiologic and histopathologic effects of targeted lung denervation in an animal model. J Appl Physiol (1985), 126(1), 67-76. doi: 10.1152/japplphysiol.00565.2018

Valipour, A., Asadi, S., Pison, C., Jondot, M., Kessler, R., Benneddif, K., (. . .) Mayse, M. (2018). Long-term safety of bilateral targeted lung denervation in patients with COPD. Int J Chron Obstruct Pulmon Dis, 13, 2163-2172. doi: 10.2147/COPD.S158748

Koegelenberg, C. F., Theron, J., Slebos, D. J., Klooster, K., Mayse, M., & Gosens, R. (2016).
Antimuscarinic Bronchodilator Response Retained after Bronchoscopic Vagal Denervation in Chronic Obstructive Pulmonary Disease Patients. Respiration, 92(1), 58-60. doi: 10.1159/000447641

Kistemaker, L. E., Slebos, D. J., Meurs, H., Kerstjens, H. A., & Gosens, R. (2015). Anti- inflammatory effects of targeted lung denervation in patients with COPD. Eur Respir J, 46(5), 1489-1492. doi: 10.1183/13993003.00413-2015

Slebos, D. J., Klooster, K., Koegelenberg, C. F., Theron, J., Styen, D., Valipour, A., (. . .) Bolliger, C. T. (2015). Targeted lung denervation for moderate to severe COPD: a pilot study. Thorax, 70(5), 411-419. doi: 10.1136/thoraxjnl-2014-206146

Targeted Lung Denervation Mechanism of Action Bibliography

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Zaccone, E. J., & Undem, B. J. (2016). Airway Vagal Neuroplasticity Associated with Respiratory Viral Infections. Lung, 194(1), 25-29. doi: 10.1007/s00408-015-9832-5

Zaccone, E. J., Lieu, T., Muroi, Y., Potenzieri, C., Undem, B. E., Gao, P., (. . . )Undem, B. J. (2016). Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways. PLoS One, 11(5), e0155526. doi: 10.1371/journal.pone.0155526

Zanini, A., Cherubino, F., Zampogna, E., Croce, S., Pignatti, P., & Spanevello, A. (2015). Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 10, 1155-1161. doi: 10.2147/COPD.S80992

McAlexander, M. A., Gavett, S. H., Kollarik, M., & Undem, B. J. (2015). Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse. Respir Physiol Neurobiol, 212-214, 20-24. doi: 10.1016/j.resp.2015.03.007

Trankner, D., Hahne, N., Sugino, K., Hoon, M. A., & Zuker, C. (2014). Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci USA, 111(31), 11515-11520. doi: 10.1073/pnas.1411032111

van den Berge, M., Vonk, J. M., Gosman, M., Lapperre, T. S., Snoeck-Stroband, J. B., Sterk, P. J., (…) Postma, D. S. (2012). Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J, 40(5), 1098-1105. doi: 10.1183/09031936.00169711

de Nijs, S. B., Fens, N., Lutter, R., Dijkers, E., Krouwels, F. H., Smids-Dierdorp, B. S., (. . .) Sterk, P. J. (2011). Airway inflammation and mannitol challenge test in COPD. Respir Res, 12, 11. doi: 10.1186/1465-9921-12-11

Zhang, G., Lin, R. L., Wiggers, M., Snow, D. M., & Lee, L. Y. (2008). Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol, 586(23), 5771-5786. doi: 10.1113/ jphysiol.2008.161042

Canning, B. J. (2006). Reflex regulation of airway smooth muscle tone. J Appl Physiol (1985), 101(3), 971-985. doi: 10.1152/japplphysiol.00313.2006

Chuaychoo, B., Hunter, D. D., Myers, A. C., Kollarik, M., & Undem, B. J. (2005). Allergeninduced substance P synthesis in large-diameter sensory neurons innervating the lungs. J Allergy Clin Immunol, 116(2), 325-331. doi: 10.1016/j.jaci.2005.04.005

Wedzicha, J. A. (2004). Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc, 1(2), 115-120. doi: 10.1513/pats.2306030

Sethi, S., Evans, N., Grant, B. J., & Murphy, T. F. (2002). New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med, 347(7), 465-471. doi: 10.1056/NEJMoa012561

Myers, A. C., Kajekar, R., & Undem, B. J. (2002). Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol, 282(4), L775-781. doi: 10.1152/ajplung.00353.2001

Carr, M. J., Hunter, D. D., Jacoby, D. B., & Undem, B. J. (2002). Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med, 165(8), 1071-1075. doi: 10.1164/ajrccm.165.8.2108065

Seemungal, T., Harper-Owen, R., Bhowmik, A., Moric, I., Sanderson, G., Message, S., (. . .) Wedzicha, J. A. (2001). Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 164(9), 1618-1623. doi: 10.1164/ajrccm.164.9.2105011

Hospers, J. J., Postma, D. S., Rijcken, B., Weiss, S. T., & Schouten, J. P. (2000). Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet, 356(9238), 1313-1317. doi: 10.1016/S0140-6736(00)02815-4

Costello, R. W., Evans, C. M., Yost, B. L., Belmonte, K. E., Gleich, G. J., Jacoby, D. B., & Fryer, A. D. (1999). Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. Am J Physiol, 276(5), L709-714. doi: 10.1152/ajplung.1999.276.5.L709

Grunberg, K., Timmers, M. C., Smits, H. H., de Klerk, E. P., Dick, E. C., Spaan, W. J.,( . . .) Sterk, P. J. (1997). Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy, 27(1), 36-45.

Sorkness, R., Clough, J. J., Castleman, W. L., & Lemanske, R. F., Jr. (1994). Virus-induced airway obstruction and parasympathetic hyperresponsiveness in adult rats. Am J Respir Crit Care Med, 150(1), 28-34. doi: 10.1164/ajrccm.150.1.8025764

Laitinen, L. A., Elkin, R. B., Empey, D. W., Jacobs, L., Mills, J., & Nadel, J. A. (1991). Bronchial hyperresponsiveness in normal subjects during attenuated influenza virus infection. Am Rev Respir Dis, 143(2), 358-361. doi: 10.1164/ajrccm/143.2.358

Fryer, A. D., & Jacoby, D. B. (1991). Parainfluenza virus infection damages inhibitory M2 muscarinic receptors on pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol, 102(1), 267-271. doi: 10.1111/j.1476-5381.1991.tb12164.x

Buckner, C. K., Songsiridej, V., Dick, E. C., & Busse, W. W. (1985). In vivo and in vitro studies on the use of the guinea pig as a model for virus-provoked airway hyperreactivity. Am Rev Respir Dis, 132(2), 305-310. doi: 10.1164/arrd.1985.132.2.305

Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., & Nadel, J. A. (1976). Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis, 113(2), 131-139. doi: 10.1164/arrd.1976.113.2.131